Urizen is the primary of the four zoas, standing for reason. Blake feels that anyone under Urizen's dominion is restricted by his limitations.
The word strongly suggests reason, the primary quality of Urizen.
Blake felt that the hegemony of rational thinking since The Enlightenment
had had a stultifying and destructive influence on the British culture.
He chose Bacon, Newton and Locke to epitomize that destructive
influence. He chose Urizen to exemplify it in his myth.
final consummation Blake rehabilitated Bacon, Newton and Locke. They
appeared counterbalancing Blake's three great poets.
Spectre was Annihilate loud thundring rejoicing terrific vanishing
Fourfold Annihilation & at the clangor of the Arrows of
Intellect J98.8; E257| The
innumerable Chariots of the Almighty appeard
in Heaven J98.9; E257| And Bacon & Newton & Locke, & Milton
& Shakspear & Chaucer (Jerusalem 98: 6-9 )
In Night II of The Four Zoas Urizen lost his faith and in vision saw the world collapsing into darkness:
FZ2: 23:9-24.8; (314)
Urizen rose from the bright Feast like a star thro' the evening sky.
First he beheld the body of Man pale, cold; the horrors of death
Beneath his feet shot thro' him as he stood in the Human Brain,
Pale he beheld futurity; pale he beheld the Abyss
Build we a Bower for heavens darling in the grizzly deep,
Build we the Mundane Shell around the Rock of Albion.